(2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

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Chemical Name:(2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate
CAS No.:100431-40-1
Molecular Formula:C₁₈H₂₆ClNO₃
Molecular Weight:339.862
Hs Code.:

Synonyms:(2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

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Chemical Property of (2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

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Technology Process of (2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

There total 2 articles about (2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2985-36-6
2-ethoxycarbonyl-4-methylpentanoic acid

: 100431-27-4
1-chloro-2(R)-amino-phenylpropane hydrochloride

: 100431-40-1
(2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; Ambient temperature;
DOI:10.1021/jm00155a027

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 100431-40-1
(2RS)-ethyl 3-<<(1R)-1-(chloromethyl)-2-phenylethyl>amino>-2-(2-methylpropyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / SOCl₂ / dimethylformamide / 2 h / 120 °C

2: 85 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl₃; tetrahydrofuran / Ambient temperature

With thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00155a027