4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

Base Information

Chemical Name:4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate
CAS No.:1430407-74-1
Molecular Formula:C₃H₄O₄*C₁₄H₁₇N₃O₄
Molecular Weight:395.369
Hs Code.:

Synonyms:4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

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Chemical Property of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

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Technology Process of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

There total 3 articles about 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.89%

: 446292-08-6,1424944-35-3
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

: 141-82-2
malonic acid

: 1430407-74-1
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

Guidance literature:: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione; With methylamine; In methanol; water; at 65 ℃; for 1h; Autoclave;

malonic acid; In methanol; water; at 25 - 30 ℃; for 24h; Time;

Reference yield:

: 446292-07-5
2-((2S)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione

: 1430407-74-1
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / Reflux

2.1: methylamine / water; methanol / 1 h / 65 °C / Autoclave

2.2: 24 h / 25 - 30 °C

With methylamine; In tetrahydrofuran; methanol; water;

Reference yield:

: 438056-69-0
4-(4-aminophenyl)morpholin-3-one

: 1430407-74-1
4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 9 h / 80 °C

2.1: tetrahydrofuran / 4 h / Reflux

3.1: methylamine / water; methanol / 1 h / 65 °C / Autoclave

3.2: 24 h / 25 - 30 °C

With methylamine; In tetrahydrofuran; methanol; ethanol; water;