3-Ethylcyclobutanecarboxylic acid

Base Information

• Chemical Name: 3-Ethylcyclobutanecarboxylic acid
• CAS No.: 66016-16-8
• Molecular Formula: C7H12O2
• Molecular Weight: 128.17
• Hs Code.: 2916209090
• Mol file: 66016-16-8.mol

Synonyms:3-Ethyl-cyclobutancarbonsaeure;3-ethylcyclobutane carboxylic acid;3-ethylcyclobutylcarboxylic acid;3-n-ethylcyclobutane-1-carboxylic acid;CYCLOBUTANECARBOXYLIC ACID,3-ETHYL;3-Ethyl-cyclobutan-1-carbonsaeure;

Chemical Property of 3-Ethylcyclobutanecarboxylic acid

Chemical Property:

• Vapor Pressure: 0.0736mmHg at 25°C
• Boiling Point: 211.1°C at 760 mmHg
• Flash Point: 97.7°C
• PSA: 37.30000
• Density: 1.061g/cm³
• LogP: 1.50720

Purity/Quality:

99% ^*data from raw suppliers

3-Ethylcyclobutanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethylcyclobutanecarboxylic acid

There total 9 articles about 3-Ethylcyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.7%

→ 3-ethylcyclobutane carboxylic acid (66016-16-8)

Guidance literature:

Reference yield:

3-Aethyl-cyclobut-1-en-carbonsaeure (89897-93-8) → 3-ethylcyclobutane carboxylic acid (66016-16-8)

Guidance literature:

With hydrogen; palladium/alumina; In pentane;

DOI:10.1021/jo01027a009

Reference yield:

methyl 3-ethyl-2-piperidinocyclobutanecarboxylate (19244-61-2) → 3-ethylcyclobutane carboxylic acid (66016-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) TsOMe, (ii) aq. KOH

2: H₂ / Pd-Al₂O₃ / pentane

With hydrogen; palladium/alumina; In pentane;

DOI:10.1021/jo01027a009

upstream raw materials:

3-Aethyl-cyclobut-1-en-carbonsaeure

ethyl diethyl malonate

diethyl malonate

1,1-bis(ethoxycarbonyl)-3-ethyl cyclobutane

Downstream raw materials:

benzyl (3-ethylcyclobutyl)carbamate

Toluene-4-sulfonic acid 3-ethyl-cyclobutylmethyl ester

1-(4'-Bromo-biphenyl-4-yl)-2-(3-ethyl-cyclobutyl)-ethanone

3-ethylcyclobutanecarboxylic acid chloride

Refernces

• 1、 Chan, L. K. M.,Gemmell, P. A.,Gray, G. W.,Lacey, D.,Toyne, K. J.. "Synthesis and Liquid Crystal Properties of Dimethylene Linked Compounds Incorporating the Cyclobutane or Spiroheptane Rings". . p. 229 - 246. Retrieved 2007/10/02.
• 2、 Shafiee, A.,Vossoghi, M.,Savabi, F.,Vlahov, R.,Tarpanov, V.,et al.. "LONG-ACTING CONTRACEPTIVE AGENTS: CYCLOPROPYL AND CYCLOBUTYL ESTERS OF NORETHISTERONE". . p. 291 - 308. Retrieved 2007/10/02.