Technology Process of 1-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxamide
There total 10 articles about 1-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
3-(1-trityl-1H-imidazol-4-yl)phenylamine;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
With
dmap;
In
N,N-dimethyl-formamide;
at 60 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetonitrile / 3 h / 20 °C
2.1: dichloromethane / 17 h / 0 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h
4.1: acetic acid / 3 h / 20 °C
5.1: methanol / 20 h / Reflux
6.1: hydrogenchloride / water; methanol / 1 h / 20 °C
7.1: triethylamine / methanol / 1 h / Reflux
8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C
8.2: 4 h / 20 °C
8.3: 60 °C
With
hydrogenchloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium fluoride / tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C
2.2: 4 h / 20 °C
2.3: 60 °C
With
potassium fluoride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
![1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxylic acid](/Databaselist/images/loading.webp)
