(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

Base Information

Chemical Name:(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate
CAS No.:1643565-09-6
Molecular Formula:C₁₉H₂₆N₄O₂
Molecular Weight:342.441
Hs Code.:

Synonyms:(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

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Chemical Property of (R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

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Technology Process of (R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

There total 10 articles about (R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1643565-41-6
C₁₉H₂₆N₄O₂

: 1643565-09-6
(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

Guidance literature:: In toluene; at 100 ℃; for 2h;
DOI:10.1039/c4ob00639a

Reference yield:

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 1643565-09-6
(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: DMP / dichloromethane / 0 - 20 °C

3: dichloromethane / 2 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5: triethylamine / dichloromethane / 3 h / 0 - 20 °C

6: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

7: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

8: toluene / 2 h / 100 °C

With lithium aluminium tetrahydride; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c4ob00639a

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1643565-09-6
(R)-tert-butyl 6-benzyl-6,7,8,9-tetrahydro[1,2,3]triazolo[1,5-a][1,4]diazocine-5(4H)carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride / 6 h

2: sodium hydrogencarbonate / ethanol / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

4: DMP / dichloromethane / 0 - 20 °C

5: dichloromethane / 2 h / 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

7: triethylamine / dichloromethane / 3 h / 0 - 20 °C

8: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

9: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

10: toluene / 2 h / 100 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium azide; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c4ob00639a