5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole

Base Information

• Chemical Name: 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole
• CAS No.: 123225-73-0
• Molecular Formula: C₂₇H₂₃N₅O₅
• Molecular Weight: 497.51
• Mol file: 123225-73-0.mol

Synonyms:5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole

Chemical Property of 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole

There total 6 articles about 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Cyanomethoxy-4-[3-(quinolin-2-ylmethoxy)-phenoxymethyl]-benzoic acid methyl ester → 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole (123225-73-0)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 - 110 ℃; for 24h;

DOI:10.1021/jm00166a017

Reference yield:

methyl 3-hydroxy-4-(hydroxymethyl)-benzoate (71780-40-0) → 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole (123225-73-0)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / acetone; dimethylformamide / 72 h / Heating

2: SOCl₂, DMF / CH₂Cl₂ / 16 h / Ambient temperature

3: NaOH / dimethylsulfoxide / 16 h / Ambient temperature

4: sodium azide, NH₄Cl / dimethylformamide / 24 h / 100 - 110 °C

With sodium hydroxide; thionyl chloride; sodium azide; potassium carbonate; ammonium chloride; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm00166a017

Reference yield:

2-[(3-hydroxyphenoxy)methyl]quinoline (107432-15-5) → 5-(2-(3-(2-quinolinylmethyloxy)phenoxymethyl)-5-carbomethoxy-phenoxymethyl)tetrazole (123225-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / dimethylsulfoxide / 16 h / Ambient temperature

2: sodium azide, NH₄Cl / dimethylformamide / 24 h / 100 - 110 °C

With sodium hydroxide; sodium azide; ammonium chloride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00166a017

upstream raw materials:

methyl 3-hydroxy-4-(hydroxymethyl)-benzoate

2-[(3-hydroxyphenoxy)methyl]quinoline

3-Cyanomethoxy-4-hydroxymethyl-benzoic acid methyl ester