5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide

Base Information

• Chemical Name: 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide
• CAS No.: 1571900-48-5
• Molecular Formula: C₁₉H₁₈F₃O₃P
• Molecular Weight: 382.319

Synonyms:5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide

Chemical Property of 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide

Chemical Property:

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Technology Process of 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide

There total 2 articles about 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ⁵-benzoxaphosphinine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3,5-dimethylphenyl ethyl [4-(trifluoromethyl)phenyl]ethynylphosphonate (1571900-29-2) → 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ5-benzoxaphosphinine 2-oxide (1571900-48-5)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 25 ℃; for 4h;

DOI:10.1002/adsc.201300545

Reference yield:

C9H4BrF3Mg (1185761-08-3) + C10H14ClO3P (1611477-79-2) → 5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ5-benzoxaphosphinine 2-oxide (1571900-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 0 °C

2: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 4 h / 25 °C

With (triphenylphosphine)gold(I) chloride; trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1002/adsc.201300545

Reference yield: 52.0%

5,7-dimethyl-2-ethoxy-4-(4-trifluoromethylphenyl)-1,2λ5-benzoxaphosphinine 2-oxide (1571900-48-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-methyl 2-ethoxy-5,7-dimethyl-4-(4-trifluoromethylphenyl)-2-oxo-2H-1,2-benzoxaphosphorine-3-acrylate

Guidance literature:

With silver(I) acetate; palladium diacetate; Trimethylacetic acid; at 80 ℃; for 24h;

DOI:10.1021/acs.orglett.5b00020

upstream raw materials:

3,5-dimethylphenyl ethyl [4-(trifluoromethyl)phenyl]ethynylphosphonate

C₉H₄BrF₃Mg

C₁₀H₁₄ClO₃P

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