[1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol

Base Information

• Chemical Name: [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol
• CAS No.: 127300-44-1
• Molecular Formula: C₁₈H₁₉ClN₂O
• Molecular Weight: 314.815
• Mol file: 127300-44-1.mol

Synonyms:[1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol

Chemical Property of [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol

There total 2 articles about [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-Chloro-1-(2-cyano-ethyl)-3-phenyl-1H-indole-2-carboxylic acid ethyl ester (127300-20-3) → [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol (127300-44-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 10h; Heating;

DOI:10.1002/jps.2600790218

Reference yield:

ethyl 3-phenyl-5-chloroindole-2-carboxylate (21139-32-2) → [1-(3-Amino-propyl)-5-chloro-3-phenyl-1H-indol-2-yl]-methanol (127300-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / timethylbenzylammonium hydroxide (Triton-B) / dioxane / 2 h / 80 °C

2: 56 percent / LiAlH₄ (LAH) / diethyl ether / 10 h / Heating

With lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; In 1,4-dioxane; diethyl ether;

DOI:10.1002/jps.2600790218

upstream raw materials:

5-Chloro-1-(2-cyano-ethyl)-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

ethyl 3-phenyl-5-chloroindole-2-carboxylate