[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Base Information

Chemical Name:[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde
CAS No.:837428-52-1
Molecular Formula:C₄₀H₅₀O₄Si₂
Molecular Weight:651.006
Hs Code.:

[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Synonyms:[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Suppliers and Price of [3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

There total 7 articles about [3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 837428-29-2
{(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-tetrahydro-2H-pyran-2-yl}-acetic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

: 837428-52-1
[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.666667h;
DOI:10.1021/ol0479242

Reference yield:

: 134341-56-3
meso-(2R,5S)-2,5-bis(tert-butyldiphenylsilyloxy)hexane-1,6-dial

: 837428-52-1
[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / NaHMDS / tetrahydrofuran; toluene / 4 h / -78 °C

2: sodium borohydride / propan-2-ol / 0 °C

3: 70 percent / DMAP / ethanol / Heating

4: 95 percent / triphenyl phosphine; DIAD / toluene / 3 h / 20 °C

5: LiOH; water / tetrahydrofuran / 2.5 h / 0 - 20 °C

6: 96 percent Spectr_. / tert-BuOK / toluene; tetrahydrofuran / 0.92 h / 0 °C

7: DIBAL-H / CH₂Cl₂; toluene / 0.67 h / -78 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium tert-butylate; water; sodium hexamethyldisilazane; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; toluene; 1: Horner-Wadsworth-Emmons reaction / 4: Mitsunobu reaction;
DOI:10.1021/ol0479242

Reference yield:

: 837428-48-5
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7S)-4,8-bis{[tert-butyl(diphenyl)silyl]oxy}-8-oxooct-2-enoate

: 837428-52-1
[3-(tert-butyl-diphenyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: sodium borohydride / propan-2-ol / 0 °C

2: 70 percent / DMAP / ethanol / Heating

3: 95 percent / triphenyl phosphine; DIAD / toluene / 3 h / 20 °C

4: LiOH; water / tetrahydrofuran / 2.5 h / 0 - 20 °C

5: 96 percent Spectr_. / tert-BuOK / toluene; tetrahydrofuran / 0.92 h / 0 °C

6: DIBAL-H / CH₂Cl₂; toluene / 0.67 h / -78 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium tert-butylate; water; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; toluene; 3: Mitsunobu reaction;
DOI:10.1021/ol0479242