ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

Base Information

Chemical Name:ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate
CAS No.:1356917-97-9
Molecular Formula:C₅₂H₄₂F₂O₄Si₂
Molecular Weight:825.071
Hs Code.:

ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

Synonyms:ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

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Chemical Property of ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

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Technology Process of ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

There total 3 articles about ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1356907-39-5
1,4-bis(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)buta-1,3-diyne

: 334868-10-9
3-(2-(ethoxycarbonylethynyl)phenyl)prop-2-ynoic acid ethyl ester

: 1356917-97-9
ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

Guidance literature:: 1,4-bis(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)buta-1,3-diyne; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S,S)-1,1'-bis(2,4-diethylphospholano)ferrocene; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 0.0833333h; Inert atmosphere;

3-(2-(ethoxycarbonylethynyl)phenyl)prop-2-ynoic acid ethyl ester; In 5,5-dimethyl-1,3-cyclohexadiene; at 100 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c1cc16762f

Reference yield:

: 107793-04-4
1,4-bis(2-bromophenyl)-1,3-butadiyne

: 1356917-97-9
ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: tetrahydrofuran / -78 °C / Inert atmosphere

3.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S,S)-1,1'-bis(2,4-diethylphospholano)ferrocene / 5,5-dimethyl-1,3-cyclohexadiene / 0.08 h / 20 °C / Inert atmosphere

3.2: 100 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; n-butyllithium; (S,S)-1,1'-bis(2,4-diethylphospholano)ferrocene; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1039/c1cc16762f

Reference yield:

: C₂₂H₂₆O₂Si₂

: 1356917-97-9
ethyl 9,9-dimethyl-3-(2-(2-(ethoxycarbonyl)ethynyl)phenyl)-4-(2-(2-(dimethyl-(2-(4-fluorophenyl)ethynyl)silyl)phenyl)ethynyl)-1-(4-fluoro)phenyl-silafluorene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 °C / Inert atmosphere

2.1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S,S)-1,1'-bis(2,4-diethylphospholano)ferrocene / 5,5-dimethyl-1,3-cyclohexadiene / 0.08 h / 20 °C / Inert atmosphere

2.2: 100 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S,S)-1,1'-bis(2,4-diethylphospholano)ferrocene; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1039/c1cc16762f