methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Base Information

• Chemical Name: methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester
• CAS No.: 209394-76-3
• Molecular Formula: C₂₂H₂₆N₂O₄
• Molecular Weight: 382.459
• Mol file: 209394-76-3.mol

Synonyms:methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Chemical Property of methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester

There total 3 articles about methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenyl-N-methylcarbamoyl chloride (4285-42-1) + 6-hydroxy-N-Boc 1-aminoindan (209394-60-5) → methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-76-3)

Guidance literature:

With sodium hydride; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/jm020120c

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Et₃N / tetrahydrofuran / 20 h / 20 °C

2: NaH / acetonitrile / 2 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm020120c

Reference yield:

1-amino-6-hydroxyindan (133497-57-1,1213899-46-7) → methyl-phenyl-carbamic acid 3-tert-butoxycarbonylamino-indan-5-yl ester (209394-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Et₃N / tetrahydrofuran / 20 h / 20 °C

2: NaH / acetonitrile / 2 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm020120c

upstream raw materials:

N-phenyl-N-methylcarbamoyl chloride

6-hydroxy-N-Boc 1-aminoindan

di-tert-butyl dicarbonate

1-amino-6-hydroxyindan