[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester
CAS No.:196491-87-9
Molecular Formula:C₃₆H₄₉NO₃Si
Molecular Weight:571.875
Hs Code.:

Synonyms:[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Suppliers and Price of [(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

There total 27 articles about [(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 223118-42-1
[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-3-(2-nonyl-[1,3]dioxolan-2-yl)-propyl]-carbamic acid benzyl ester

: 196491-87-9
[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Guidance literature:: With toluene-4-sulfonic acid; In water; acetone; for 2.5h; Heating;
DOI:10.1039/a808840c

Reference yield:

: 196491-68-6
3-[dimethyl(phenyl)silyl]glutaric anhydride

: 196491-87-9
[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: 100 percent / tetrahydrofuran / 24 h / 30 °C

2: Et₃N / 1 h / -78 - 0 °C

3: DMAP / 24 h / Ambient temperature

4: H₂ / 10percent Pd/C / 24 h / Ambient temperature

5: Et₃N / 1 h / -78 - 0 °C

6: 48 h / -25 °C

7: Me₃SiOSO₂CF₃ / 48 h / -20 °C

8: tetrahydrofuran / 18 h / 30 °C

9: 88 percent / LiTMP, DMPU / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 to -10 deg C, 60 h

10: aq. KOH / H₂O / 32 h / 80 °C

11: 0.5 h / Ambient temperature

12: NH₃

13: Pb(OAc)4 / dimethylformamide / 15 h / 100 °C

14: TsOH / acetone; H₂O / 2.5 h / Heating

With lead(IV) acetate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; 2,2,6,6-tetramethylpiperidinyl-lithium; ammonia; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/a703387g

Reference yield:

: 5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(dimethyl-phenyl-silanyl)-5-oxo-pentanoic acid

: 196491-87-9
[(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: Et₃N / 1 h / -78 - 0 °C

2: DMAP / 24 h / Ambient temperature

3: H₂ / 10percent Pd/C / 24 h / Ambient temperature

4: Et₃N / 1 h / -78 - 0 °C

5: 48 h / -25 °C

6: Me₃SiOSO₂CF₃ / 48 h / -20 °C

7: tetrahydrofuran / 18 h / 30 °C

8: 88 percent / LiTMP, DMPU / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 to -10 deg C, 60 h

9: aq. KOH / H₂O / 32 h / 80 °C

10: 0.5 h / Ambient temperature

11: NH₃

12: Pb(OAc)4 / dimethylformamide / 15 h / 100 °C

13: TsOH / acetone; H₂O / 2.5 h / Heating

With lead(IV) acetate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; 2,2,6,6-tetramethylpiperidinyl-lithium; ammonia; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/a703387g