{[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

Base Information

• Chemical Name: {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester
• CAS No.: 851513-73-0
• Molecular Formula: C₂₈H₃₆N₂O₇
• Molecular Weight: 512.603
• Mol file: 851513-73-0.mol

Synonyms:{[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

Chemical Property of {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

There total 5 articles about {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-((benzyloxycarbonylamino)methyl)benzoic acid (58933-52-1) + tert-butyl iminodiacetate (85916-13-8) → {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester (851513-73-0)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ja028574m

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester (851513-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂O / 0 - 20 °C

2: 80 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 4 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;

DOI:10.1021/ja0317731

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → {[4-(benzyloxycarbonylamino-methyl)-benzoyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester (851513-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂O / 0 - 20 °C

2: 80 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 4 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;

DOI:10.1021/ja0317731

upstream raw materials:

4-((benzyloxycarbonylamino)methyl)benzoic acid

tert-butyl iminodiacetate

p-aminomethylbenzoic acid

benzyl chloroformate

Downstream raw materials:

[tert-butoxycarbonylmethyl-(4-aminomethyl-benzoyl)-amino]-acetic acid tert-butyl ester