((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

Base Information

Chemical Name:((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile
CAS No.:1418200-12-0
Molecular Formula:C₂₃H₂₃N₅O₃S
Molecular Weight:449.533
Hs Code.:

Synonyms:((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

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Chemical Property of ((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

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Technology Process of ((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

There total 10 articles about ((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1418200-11-9
((1R,3S)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-acetonitrile

: 1418200-12-0
((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1418200-07-3
(1R,3S)-3-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid methyl ester

: 1418200-12-0
((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / 80 °C

2.1: 1H-imidazole / dichloromethane / 20 °C

3.1: sodium tetrahydroborate / ethanol / 20 °C

4.1: dmap / dichloromethane / 30 h / 20 °C

5.1: water; dimethyl sulfoxide / 3 h / 60 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; tetrabutyl ammonium fluoride; triethyloxonium fluoroborate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1418200-06-2
(1R,3S)-3-( 1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid methyl ester

: 1418200-12-0
((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxy-ethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; iron / water; methanol / 3 h / 80 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 2 h / 20 °C

2.2: 2 h / 80 °C

3.1: 1H-imidazole / dichloromethane / 20 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: dmap / dichloromethane / 30 h / 20 °C

6.1: water; dimethyl sulfoxide / 3 h / 60 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; tetrabutyl ammonium fluoride; triethyloxonium fluoroborate; iron; ammonium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;