(2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene

Base Information

• Chemical Name: (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene
• CAS No.: 130082-70-1
• Molecular Formula: C₁₇H₂₂
• Molecular Weight: 226.362
• Mol file: 130082-70-1.mol

Synonyms:(2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene

Chemical Property of (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene

There total 12 articles about (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2E/Z,3aα,7aβ)-methyl 2,4,6-tris(1-methylethyl)benzenesulfonate (130082-72-3) → (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene (130082-70-1)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; Heating;

DOI:10.1039/c39900000972

Reference yield: 42.0%

(2E/Z,3aα,7aβ)-methyl 4-methylbenzenesulfonate → (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene (130082-70-1) + (3aα,7aβ)-Octahydro-2-(phenylmethylene)-3aH-indene-3a-methanol (130082-69-8)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; for 15h; Heating;

DOI:10.1021/jo00076a057

Reference yield:

(3aα,7aβ)-Octahydro-2-(phenylmethylene)-3aH-indene-3a-methanol (130082-69-8) → (2E/Z,3aα,7aβ)-Octahydro-3a-methyl-2-(phenylmethylene)-1H-indene (130082-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / pyridine / 80 °C

2: 94 percent / LiEt₃BH / tetrahydrofuran / 12 h / Heating

With pyridine; lithium triethylborohydride; In tetrahydrofuran;

DOI:10.1021/jo00076a057

upstream raw materials:

(2E/Z,3aα,7aβ)-methyl 2,4,6-tris(1-methylethyl)benzenesulfonate

3-hydroxymethylcyclohexene

(3aα,7aβ)-Octahydro-2-(phenylmethylene)-3aH-indene-3a-methanol

Se-Phenyl O-(2-cyclohexen-1-ylmethyl)selenocarbonate

Downstream raw materials:

trans-Octahydro-3a-methyl-2H-inden-2-one