(1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Base Information

• Chemical Name: (1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide
• CAS No.: 928844-28-4
• Molecular Formula: C₃₉H₅₀N₄O₆S
• Molecular Weight: 702.915

Synonyms:(1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Chemical Property of (1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

There total 13 articles about (1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)- (959983-22-3) + (-)-3-endo-aminobornan-2-endo-ol → (1aS,12bR)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-29-5) + (1aR,12bS)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-28-4)

Guidance literature:

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

(-)-3-endo-aminobornan-2-endo-ol; In dimethyl sulfoxide; at 20 ℃;

Reference yield: 36.0%

(2S)-3-exo-aminoisoborneol (41719-73-7) → (1aS,12bR)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-29-5) + (1aR,12bS)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-28-4)

Guidance literature:

(±) 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

(2S)-3-exo-aminoisoborneol; In dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity;

Reference yield: 36.0%

(1aR/S)-[partial]-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide → (1aS,12bR)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-29-5) + (1aR,12bS)-8-cyclohexyl-N5-[(dimethylamino)sulfonyl]-1,12b-dihydro-N1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide (928844-28-4)

Guidance literature:

In water; acetonitrile; trifluoroacetic acid; Purification / work up;

upstream raw materials:

(2S)-3-exo-aminoisoborneol

cycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid, 8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxy-, (+/-)-

methyl 3-cyclohexyl-1H-indole-6-carboxylate

methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

Downstream raw materials:

(1aR,12bS)-8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxycycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 8-cyclohexyl-N-[(dimethylamino)sulfonyl]-1a-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1,1a,2,12b-tetrahydro-11-methoxy-, (1aR,12bS)-

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 928844-28-4 (1aR,12bS)-8-cyclohexyl-N⁵-[(dimethylamino)sulfonyl]-1,12b-dihydro-N^1a-[(2R,3S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-11-methoxy-cycloprop[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send