7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 1456620-64-6
• Molecular Formula: C₂₂H₂₂F₂N₄O₃
• Molecular Weight: 428.438

Synonyms:7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property of 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

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Technology Process of 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 3 articles about 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-ethyl-6-fluoro-7-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1456620-63-5) → 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1456620-64-6)

Guidance literature:

With palladium on activated charcoal; hydrazine hydrate; In butan-1-ol; at 150 ℃; for 0.833333h; Microwave irradiation;

DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (70458-96-7) → 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1456620-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 0.07 h / 100 °C / Microwave irradiation

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 0.83 h / 150 °C / Microwave irradiation

With palladium on activated charcoal; sodium hydrogencarbonate; hydrazine hydrate; In butan-1-ol;

DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 7-[4-(4-amino-2-fluorophenyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (1456620-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 0.07 h / 100 °C / Microwave irradiation

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 0.83 h / 150 °C / Microwave irradiation

With palladium on activated charcoal; sodium hydrogencarbonate; hydrazine hydrate; In butan-1-ol;

DOI:10.1016/j.ejmech.2013.06.045

upstream raw materials:

1-ethyl-6-fluoro-7-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

3,4-difluoronitrobenzene

Downstream raw materials:

1-ethyl-6-fluoro-7-[4-({2-methoxy-4-[({[4-(2-methoxyphenyl)piperazin-1-yl]acetyl}hydrazono)methyl]phenoxy}acetyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-{4-[({5-[4-(2-methoxyphenyl)piperazin-1-yl]-1,3,4-oxadiazol-2-yl}thio)acetyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-(4-{[(5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)thio]acetyl}piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-7-{4-[(2-{[4-(2-methoxyphenyl)piperazin-1-yl]acetyl}hydrazino)acetyl]piperazin-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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