methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

Base Information

Chemical Name:methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate
CAS No.:1383575-13-0
Molecular Formula:C₂₁H₃₃N₃O₄
Molecular Weight:391.511
Hs Code.:

Synonyms:methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

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Chemical Property of methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

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Technology Process of methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

There total 1 articles about methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 57611-57-1
methyl 4-amino-1-benzylpiperidine-4-carboxylate

: 1383575-13-0
methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

Guidance literature:: N-(t-butoxycarbonyl)glycinal; methyl 4-amino-1-benzylpiperidine-4-carboxylate; With sodium acetate; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 0.0833333h;

Reference yield: 60.0%

: 1383575-13-0
methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

: 1274752-07-6
9-benzyl-1,4,9-triazaspiro[5.5]undecan-5-one

Guidance literature:: methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; at 0 ℃; for 22h; Reflux;

Reference yield:

: 1383575-13-0
methyl 1-benzyl-4-((2-((tert-butoxycarbonyl)amino)ethyl)amino)piperidine-4-carboxylate

: 1383572-91-5
9-(4,6-dimethylpyrimidin-2-yl)-4-((1-methyl-4-phenyl-1H-pyrazol-3-yl)methyl)-1,4,9-triazaspiro[5.5]undecan-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

1.2: 22 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 112 h / 20 °C

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 20 °C / 37503.8 Torr

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 120 °C / microwave irradiation; sealed tube

5.1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 0.67 h / 0 °C

5.2: 5.5 h / 0 - 20 °C

6.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 16 h / 93 °C / Inert atmosphere

6.2: 1.5 h / 20 °C

6.3: pH 10

With potassium phosphate; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 10 wt% Pd(OH)2 on carbon; palladium diacetate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; toluene;