methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Base Information

Chemical Name:methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate
CAS No.:171897-35-1
Molecular Formula:C₁₉H₁₈ClNO₄
Molecular Weight:359.809
Hs Code.:

Synonyms:methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Suppliers and Price of methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

There total 4 articles about methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 169774-59-8
methyl (2S)-1-benzoyl-4-oxo-2-pyrrolidinecarboxylate

: 171897-35-1
methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Guidance literature:: With cerium(III) chloride; In diethyl ether; for 3h; Ambient temperature;
DOI:10.1248/cpb.43.1302

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 171897-35-1
methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / aq. Na₂CO₃ / 4 h / 0 °C

2: 1.) DMSO, (COCl)2, 2.) NEt₃ / 1.) CH₂Cl₂, from -60 to -50 deg C, 2 h, 2.) CH₂Cl₂, from -60 to -50 deg C, 4 h

3: 78 percent / CeCl₃ / diethyl ether / 3 h / Ambient temperature

With cerium(III) chloride; oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; triethylamine; In diethyl ether;
DOI:10.1248/cpb.43.1302

Reference yield:

: 31560-20-0,120806-96-4
(2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: 171897-35-1
methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DMSO, (COCl)2, 2.) NEt₃ / 1.) CH₂Cl₂, from -60 to -50 deg C, 2 h, 2.) CH₂Cl₂, from -60 to -50 deg C, 4 h

2: 78 percent / CeCl₃ / diethyl ether / 3 h / Ambient temperature

With cerium(III) chloride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In diethyl ether;
DOI:10.1248/cpb.43.1302