3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester
CAS No.:1402345-23-6
Molecular Formula:C₂₄H₁₇FN₂O₅
Molecular Weight:432.408
Hs Code.:

Synonyms:3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

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Chemical Property of 3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

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Technology Process of 3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

There total 10 articles about 3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402345-22-5
3-fluoro-4-{3-[2-(methoxyoxalyl-phenyl-amino)-pyridin-3-yl]-3-oxo-propyl}-benzoic acid methyl ester

: 1402345-23-6
3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Guidance literature:: 3-fluoro-4-{3-[2-(methoxyoxalyl-phenyl-amino)-pyridin-3-yl]-3-oxo-propyl}-benzoic acid methyl ester; With potassium carbonate; In methanol; at 85 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 55676-21-6
3-acetyl-2-chloropyridine

: 1402345-23-6
3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DL-10-camphorsulfonic acid / 1,4-dioxane / 3 h / 75 - 80 °C / Sealed tube

2: sodium methylate / methanol / 48 h / 25 °C

3: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 18 h / 25 °C

4: toluene / 5 h / 130 °C

5: potassium carbonate / methanol / 3 h / 85 °C

With hydrogen; sodium methylate; potassium carbonate; platinum(IV) oxide; DL-10-camphorsulfonic acid; In 1,4-dioxane; methanol; ethyl acetate; toluene; 2: Aldol Condensation;

Reference yield:

: 74733-25-8
methyl 3-fluoro-4-formylbenzoate

: 1402345-23-6
3-(4-carboxy-2-fluoro-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / methanol / 48 h / 25 °C

2: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 18 h / 25 °C

3: toluene / 5 h / 130 °C

4: potassium carbonate / methanol / 3 h / 85 °C

With hydrogen; sodium methylate; potassium carbonate; platinum(IV) oxide; In methanol; ethyl acetate; toluene; 1: Aldol Condensation;