2-benzyloxy-5-hydroxymethylbenzonitrile

Base Information

• Chemical Name: 2-benzyloxy-5-hydroxymethylbenzonitrile
• CAS No.: 946007-64-3
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Mol file: 946007-64-3.mol

Synonyms:2-benzyloxy-5-hydroxymethylbenzonitrile

Chemical Property of 2-benzyloxy-5-hydroxymethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxy-5-hydroxymethylbenzonitrile

There total 4 articles about 2-benzyloxy-5-hydroxymethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-benzyloxy-3-cyanobenzoyl chloride (556836-18-1) → 2-benzyloxy-5-hydroxymethylbenzonitrile (946007-64-3)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm061462b

Reference yield:

4-(benzyloxy)-3-cyanobenzoic acid (946007-61-0) → 2-benzyloxy-5-hydroxymethylbenzonitrile (946007-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / Heating

2: 93 percent / NaBH₄ / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; ethanol;

DOI:10.1021/jm061462b

Reference yield:

3-cyano-4-fluorobenzoic acid (171050-06-9) → 2-benzyloxy-5-hydroxymethylbenzonitrile (946007-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NaH / dimethylsulfoxide / 4 h / 20 °C

2: 100 percent / SOCl₂ / Heating

3: 93 percent / NaBH₄ / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium hydride; In tetrahydrofuran; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm061462b

upstream raw materials:

4-benzyloxy-3-cyanobenzoyl chloride

4-(benzyloxy)-3-cyanobenzoic acid

3-cyano-4-fluorobenzoic acid

2-fluoro-5-formylbenzonitrile

Downstream raw materials:

2-benzyloxy-5-chloromethylbenzonitrile

2-benzyloxy-5-{[(4-cyanophenyl)[1,2,4]triazol-4-ylamino]methyl}benzonitrile

C₁₇H₁₂N₆O

Refernces