tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate
CAS No.:1082950-40-0
Molecular Formula:C₂₀H₂₄F₃N₃O₂
Molecular Weight:395.425
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1082950-12-6
4-[4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 1082950-40-0
tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃;

Reference yield:

: 1082949-93-6
4-[2-oxo-2-(3-trifluoromethyl-phenyl)-ethylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

: 1082950-12-6
4-[4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine

: 1082950-40-0
tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: With ammonium acetate; In methanol; at 170 ℃; for 5h;
DOI:10.1021/op200351g

Reference yield:

: 1082951-11-8
(2-amino-1-(3-trifluoromethyl-phenyl)ethanone) p-toluenesulfonate

: 1082950-12-6
4-[4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine

: 1082950-40-0
tert-butyl 4-(4-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 0.42 h / 0 - 5 °C / Inert atmosphere

1.2: 5 - 20 °C

2.1: ammonium acetate / methanol / 5 h / 170 °C

With ammonium acetate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/op200351g