(1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester

Base Information

• Chemical Name: (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester
• CAS No.: 813458-28-5
• Molecular Formula: C₂₄H₂₄N₂O₄
• Molecular Weight: 404.466
• Mol file: 813458-28-5.mol

Synonyms:(1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester

Chemical Property of (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester

There total 2 articles about (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.0^2,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S,3S,4S,5R,6R)-3,4-Dibromo-7,8-diaza-tricyclo[4.2.2.02,5]dec-9-ene-7,8-dicarboxylic acid dibenzyl ester → (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.02,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester (813458-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂; PtO₂; H₂ / ethanol; tetrahydrofuran / 23 °C / 760 Torr

2: 27.5 g / AcOH; Zn / 32 h

With platinum(IV) oxide; hydrogen; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; ethanol;

DOI:10.1021/ja044089a

Reference yield:

(1S,2S,3S,4S,5R,6R)-3,4-Dibromo-7,8-diaza-tricyclo[4.2.2.02,5]decane-7,8-dicarboxylic acid dibenzyl ester → (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.02,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester (813458-28-5)

Guidance literature:

With acetic acid; zinc; for 32h;

DOI:10.1021/ja044089a

Reference yield: 40.0%

cyclopent-2-enone (930-30-3) + (1R,2R,5S,6S)-7,8-Diaza-tricyclo[4.2.2.02,5]dec-3-ene-7,8-dicarboxylic acid dibenzyl ester (813458-28-5) → C29H30N2O5

Guidance literature:

In acetonitrile; at 23 ℃; for 36h; UV-irradiation;

DOI:10.1021/ja044089a