N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

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Chemical Name:N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide
CAS No.:1561810-95-4
Molecular Formula:C₃₁H₃₀N₆O₂
Molecular Weight:518.618
Hs Code.:

Synonyms:N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

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Chemical Property of N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

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Technology Process of N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

There total 13 articles about N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1561810-95-4
N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield: 28.0%

: 1561810-60-3
4-amino-N-(2-methyl-5-(morpholin-4-ylmethyl)phenyl)benzamide

: 1561811-16-2
2-chloro-4-phenylpyrrolo[2,1-f][1,2,4]triazine

: 1561810-95-4
N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 150 ℃; for 3h; Microwave irradiation;
DOI:10.1016/j.bmc.2013.12.055

Reference yield:

: 159326-66-6
N-amino-1H-pyrrole-2-carbonitrile

: 1561810-95-4
N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 20 °C

2.1: pyridine / 1,4-dioxane / 0.25 h

2.2: 1 h / Reflux

3.1: sodium ethanolate / ethanol / 2 h / Reflux

4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere

6.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 3 h / 150 °C / Microwave irradiation

With pyridine; bis-triphenylphosphine-palladium(II) chloride; water; sodium ethanolate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5.1: |Suzuki Coupling / 6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055