Technology Process of N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide
There total 13 articles about N-{2-methyl-5-[(morpholinyl)methyl]phenyl}-4-({4-phenylpyrrolo[2,1-f][1,2,4]triazin-2-yl}amino)benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 17h;
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane;
at 150 ℃;
for 3h;
Microwave irradiation;
DOI:10.1016/j.bmc.2013.12.055
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide; water / 20 °C
2.1: pyridine / 1,4-dioxane / 0.25 h
2.2: 1 h / Reflux
3.1: sodium ethanolate / ethanol / 2 h / Reflux
4.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 24 h / 120 °C
5.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide; water / 16 h / 80 °C / Inert atmosphere
6.1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 3 h / 150 °C / Microwave irradiation
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; water; sodium ethanolate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; trichlorophosphate;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
5.1: |Suzuki Coupling / 6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.12.055