1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

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Chemical Name:1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one
CAS No.:686268-57-5
Molecular Formula:C₂₃H₁₈N₄O₅S
Molecular Weight:462.486
Hs Code.:

Synonyms:1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

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Chemical Property of 1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

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Technology Process of 1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

There total 8 articles about 1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Methoxy-2-nitro-1-phenylmethanesulfonyl-benzene

: 686268-57-5
1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / aq. NH₃ / CH₂Cl₂ / 0.5 h / 5 °C

2.1: 71 percent / Fe; aq. NH₄Cl / methanol / 1.5 h / Heating

3.1: Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

4.1: 82 percent / Na₂CO₃ / ethanol / 3.5 h / Heating

5.1: NaH / tetrahydrofuran / Heating

5.2: HOAc / tetrahydrofuran / Heating

With ammonium hydroxide; iron; sodium hydride; sodium carbonate; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.022

Reference yield:

: N-(5-methoxy-2-sulfamoyl-phenyl)-malonamic acid ethyl ester

: 686268-57-5
1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / Na₂CO₃ / ethanol / 3.5 h / Heating

2.1: NaH / tetrahydrofuran / Heating

2.2: HOAc / tetrahydrofuran / Heating

With sodium hydride; sodium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2006.04.022

Reference yield:

: 22057-42-7
2-Nitro-4-methoxy-1-benzylmercapto-benzol

: 686268-57-5
1-benzyl-4-hydroxy-3-(6-methoxy-1, 1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: Cl₂; HOAc; H₂O / 0.25 h / 5 °C

2.1: 88 percent / aq. NH₃ / CH₂Cl₂ / 0.5 h / 5 °C

3.1: 71 percent / Fe; aq. NH₄Cl / methanol / 1.5 h / Heating

4.1: Et₃N / CH₂Cl₂ / 3.5 h / 20 °C

5.1: 82 percent / Na₂CO₃ / ethanol / 3.5 h / Heating

6.1: NaH / tetrahydrofuran / Heating

6.2: HOAc / tetrahydrofuran / Heating

With ammonium hydroxide; water; chlorine; iron; sodium hydride; sodium carbonate; ammonium chloride; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.04.022