4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

Base Information

Chemical Name:4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt
CAS No.:1181965-77-4
Molecular Formula:C₂₃H₂₀F₃N₂O₃*Na
Molecular Weight:452.408
Hs Code.:

Synonyms:4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

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Chemical Property of 4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

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Technology Process of 4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

There total 4 articles about 4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181964-57-7
4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid

: 1181965-77-4
4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

Guidance literature:: With sodium hydroxide; In methanol; dichloromethane; for 2h;

Reference yield:

: 4-[4-(trifluoromethyl)phenyl]piperidine hydrochloride

: 1181965-77-4
4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; triethylamine / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation

2: sodium hydroxide / tetrahydrofuran; ethanol / 64 h

3: sodium hydroxide / methanol; dichloromethane / 2 h

With acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 337909-10-1
1-formyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester

: 1181965-77-4
4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; triethylamine / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation

2: sodium hydroxide / tetrahydrofuran; ethanol / 64 h

3: sodium hydroxide / methanol; dichloromethane / 2 h

With acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane;