trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

Base Information

Chemical Name:trans-3-bromo-4-fluorocinnamic acid tert-butyl ester
CAS No.:370867-82-6
Molecular Formula:C₁₃H₁₄BrFO₂
Molecular Weight:301.155
Hs Code.:

Synonyms:trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

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Chemical Property of trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

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Technology Process of trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

There total 1 articles about trans-3-bromo-4-fluorocinnamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 370867-85-9
3-(3-bromo-4-fluorophenyl)acrylic acid

: 370867-82-6
trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 14h;
DOI:10.1021/jm010100v

Reference yield:

: 24470-78-8
isopropyltriphenylphosphonium iodide

: 370867-82-6
trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

: (1R,3S)-3-(3-Bromo-4-fluoro-phenyl)-2,2-dimethyl-cyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: isopropyltriphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

trans-3-bromo-4-fluorocinnamic acid tert-butyl ester; In tetrahydrofuran; hexane; at 0 - 25 ℃; Further stages.;
DOI:10.1021/jm010100v

Reference yield:

: 370867-82-6
trans-3-bromo-4-fluorocinnamic acid tert-butyl ester

: (1R,3S)-3-(3-Bromo-4-fluoro-phenyl)-2,2-dimethyl-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: hexane; tetrahydrofuran / 0 - 25 °C

2.1: TFA / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm010100v