N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

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Chemical Name:N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride
CAS No.:1386398-58-8
Molecular Formula:C₂₆H₃₂N₈*ClH
Molecular Weight:493.055
Hs Code.:

Synonyms:N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

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Chemical Property of N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

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Technology Process of N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

There total 11 articles about N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386399-51-4
(4-{3-[3-(3-tert-butoxycarbonylamino-1-phenyl-propylamino)-phenyl]-1-trityl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-cyclohexyl)-carbamic acid tert-butyl ester

: 1386398-58-8
N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: With hydrogenchloride; water; In ethanol; at 20 ℃; for 15h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1386398-58-8
N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -35 °C / Inert atmosphere

1.2: 2 h / -35 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate / dichloromethane; water / 2 h / 0 °C

3.1: hydrazine / tetrahydrofuran; water / 0.67 h / 20 - 50 °C

4.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 120 °C

6.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Sealed tube

7.1: hydrogenchloride; water / ethanol / 15 h / 20 °C

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; isopropylmagnesium chloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1047644-72-3
[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propyl]-carbamic acid tert-butyl ester

: 1386398-58-8
N-{3-[3-(3-amino-1-phenyl-propylamino)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / tetrahydrofuran; methanol; water / 6 h / 65 °C

2: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride; water / ethanol / 15 h / 20 °C

With hydrogenchloride; water; potassium carbonate; hydrazine hydrate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;