[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

Base Information

Chemical Name:[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine
CAS No.:1092504-93-2
Molecular Formula:C₂₄H₂₂ClN₅O₂
Molecular Weight:447.924
Hs Code.:

Synonyms:[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

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Chemical Property of [((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

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Technology Process of [((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

There total 14 articles about [((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092506-51-8
4-(3-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid

: 1092506-50-7
[(1R,2S,5S)-3-azabicyclo[3.1.0]hex-2-ylmethyl]-1,3-benzoxazol-2-amine

: 1092504-93-2
[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: C₁₅H₁₉NO₅S

: 1092504-93-2
[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 15 h / 90 °C

2: polymer-bound triphenylphosphine; water / tetrahydrofuran / 2 h / 50 °C

3: triethylamine / N,N-dimethyl-formamide / 24 h / 20 - 25 °C

4: hexanes; diethylamine; isopropyl alcohol / 0.14 h / Resolution of racemate

5: hydrogen / palladium dihydroxide / ethanol; ethyl acetate / 1 h / 20 - 25 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With sodium azide; polymer-bound triphenylphosphine; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In tetrahydrofuran; hexanes; ethanol; dichloromethane; ethyl acetate; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1092506-48-3
benzyl (1R,2S,5S)-2-[(1,3-benzoxazol-2-ylamino)methyl]-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1092504-93-2
[((1R,2S,5S)-3-{[4-(3-chlorophenyl)-1-methyl-1H-pyrazol-3-yl]carbonyl}-3-azabicyclo[3.1.0]hex-2-yl)methyl]-1,3-benzoxazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium dihydroxide / ethanol; ethyl acetate / 1 h / 20 - 25 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In ethanol; dichloromethane; ethyl acetate;