N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide

Base Information

• Chemical Name: N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide
• CAS No.: 1207079-05-7
• Molecular Formula: C₂₄H₂₂F₆N₄O₂
• Molecular Weight: 512.455
• Mol file: 1207079-05-7.mol

Synonyms:N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide

Chemical Property of N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide

There total 5 articles about N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-1H-isoindole-1,3(2H)-dione (1207088-77-4) + isopropylamine (75-31-0) → N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide (1207079-05-7)

Guidance literature:

acetic acid; In 1,4-dioxane; for 3h; Reflux;

Reference yield:

4-(chloromethyl)-2-methyl-1-nitro-benzene (18515-14-5) → N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide (1207079-05-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: iron; acetic acid / 5 h / 40 °C

3: acetic acid / 3 h / Reflux

4: acetic acid / 1,4-dioxane / 3 h / Reflux

With iron; potassium carbonate; acetic acid; acetic acid; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (866638-66-6) → N-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-N'-[(1-methylethyl)]-1,2-benzenedicarboxamide (1207079-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; acetic acid / 5 h / 40 °C

2: acetic acid / 3 h / Reflux

3: acetic acid / 1,4-dioxane / 3 h / Reflux

With iron; acetic acid; acetic acid; In 1,4-dioxane; acetic acid;

upstream raw materials:

2-(4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-methylphenyl)-1H-isoindole-1,3(2H)-dione

isopropylamine

4-(chloromethyl)-2-methyl-1-nitro-benzene

1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole