N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline

Base Information

• Chemical Name: N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline
• CAS No.: 212504-05-7
• Molecular Formula: C₂₀H₁₁BrF₄N₂O₃
• Molecular Weight: 483.217

Synonyms:N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline

Chemical Property of N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline

Chemical Property:

Purity/Quality:

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Technology Process of N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline

There total 2 articles about N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-(2,6-difluorobenzoyl)-4-bromo-2-nitroaniline (212504-04-6) + 2,6-Difluorobenzyl bromide (85118-00-9) → N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline (212504-05-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 6h;

DOI:10.1021/jm060103d

Reference yield:

2,6-difluoro-N-(2-nitrophenyl)benzamide (199594-48-4) → N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline (212504-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / pyridine; Br₂; AcOH / tetrahydrofuran / 1 h / 20 °C

2: 74 percent / NaH / tetrahydrofuran / 6 h

With pyridine; bromine; sodium hydride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm060103d

Reference yield: 62.0%

N-(2,6-difluorobenzoyl)-N-(2,6-difluorobenzyl)-4-bromo-2-nitroaniline (212504-05-7) → 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-5-bromo-benzimidazole

Guidance literature:

With iron; acetic acid; for 0.5h; Heating;

DOI:10.1021/jm060103d

upstream raw materials:

N-(2,6-difluorobenzoyl)-4-bromo-2-nitroaniline

2,6-Difluorobenzyl bromide

2,6-difluoro-N-(2-nitrophenyl)benzamide

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