(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:1270077-70-7
Molecular Formula:C₄₅H₅₀ClN₅O₅Si
Molecular Weight:804.461
Hs Code.:

(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

Synonyms:(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of (3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of (3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

There total 8 articles about (3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1269755-13-6
(3S,4S)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid

: 1270075-90-5
5'-chloro-N₆-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine

: 1270077-70-7
(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: (3S,4S)-1-(benzyloxycarbonyl)-4-(tert-butyldiphenylsilyloxy)-pyrrolidine-3-carboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 - 20 ℃; for 0.5h;

5'-chloro-N₆-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine; With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 144100-07-2
2-bromo-6-fluoropyridine

: 1270077-70-7
(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dimethyl sulfoxide / 18 h / 110 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 103 °C

3.1: ammonium hydroxide / water; dimethyl sulfoxide / 96 h / 140 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

4.2: 1 h / 20 °C

With ammonium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1263374-09-9
6-bromo-N-((tetrahydro-2H-pyran-4-yl)methyl)pyridin-2-amine

: 1270077-70-7
(3S,4S)-3-(tert-butyldiphenylsilanyloxy)-4-{5'-chloro-6-[(tetrahydropyran-4-ylmethyl)amino]-[2,4']bipyridinyl-2'-ylcarbamoyl}pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 103 °C

2.1: ammonium hydroxide / water; dimethyl sulfoxide / 96 h / 140 °C

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

3.2: 1 h / 20 °C

With ammonium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;