2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

Base Information

Chemical Name:2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine
CAS No.:1609654-74-1
Molecular Formula:C₁₇H₁₉F₃N₂O₂
Molecular Weight:340.345
Hs Code.:

Synonyms:2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

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Chemical Property of 2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

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Technology Process of 2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

There total 2 articles about 2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609654-75-2
(5-(tert-butyl)-2-(methoxymethoxy)phenyl)boronic acid

: 69034-12-4
2-chloro-5-(trifluoromethyl)pyrimidine

: 1609654-74-1
2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

Guidance literature:: (5-(tert-butyl)-2-(methoxymethoxy)phenyl)boronic acid; 2-chloro-5-(trifluoromethyl)pyrimidine; With sodium carbonate; In 1,2-dimethoxyethane; water; for 0.0833333h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 271600-96-5
methoxymethyl ether of p-tert-butylphenol

: 1609654-74-1
2-(5-(tert-butyl)-2-(methoxymethoxy)phenyl)-5-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / pentane / 0 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: sodium carbonate / 1,2-dimethoxyethane; water / 0.08 h / Inert atmosphere

2.2: 16 h / 80 °C / Inert atmosphere; Sealed tube

With tert.-butyl lithium; sodium carbonate; In 1,2-dimethoxyethane; water; pentane; 2.1: |Suzuki Coupling;