(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

Base Information

Chemical Name:(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide
CAS No.:1382859-53-1
Molecular Formula:C₂₅H₂₈BrN₃O₃
Molecular Weight:498.42
Hs Code.:

Synonyms:(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

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Chemical Property of (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

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Technology Process of (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

There total 4 articles about (S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382859-66-6
(+/-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

: 1382859-54-2
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

: 1382859-53-1
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

Guidance literature:: With Lux Amylose-2; In hexane; isopropyl alcohol; at 40 ℃; Resolution of racemate;
DOI:10.1016/j.bmc.2012.04.043

Reference yield:

: 616-05-7
2-bromohexanoic acid

: 1382859-54-2
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

: 1382859-53-1
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 4 h / 40 °C

2: tetrahydrofuran / 4 h / 20 °C

3: potassium carbonate / acetonitrile / Reflux

4: Lux Amylose-2.(R). / hexane; isopropyl alcohol / 40 °C / Resolution of racemate

With thionyl chloride; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2012.04.043

Reference yield:

: 42768-46-7
2-bromohexanoyl chloride

: 1382859-54-2
(R)-(-)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

: 1382859-53-1
(S)-(+)-N-(4-bromophenyl)-2-[5-(3-methoxybenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl]hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 4 h / 20 °C

2: potassium carbonate / acetonitrile / Reflux

3: Lux Amylose-2.(R). / hexane; isopropyl alcohol / 40 °C / Resolution of racemate

With potassium carbonate; In tetrahydrofuran; hexane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmc.2012.04.043