3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

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Chemical Name:3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile
CAS No.:1456892-09-3
Molecular Formula:C₂₄H₂₀ClN₅O₂
Molecular Weight:445.908
Hs Code.:

Synonyms:3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

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Chemical Property of 3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

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Technology Process of 3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

There total 4 articles about 3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1456892-58-2
C₂₀H₁₇BrClN₃O₂

: 153435-63-3
2-(tributylstannyl)pyrimidine

: 1456892-09-3
3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere; Microwave irradiation;

Reference yield:

: 2840-02-0
5-acetamido-2-bromobenzoic acid

: 1456892-09-3
3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.58 h / 0 °C

1.2: 0.25 h / 60 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 1 h / 25 °C

2.2: 1.5 h / 80 °C

3.1: cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; cesium fluoride; sodium nitrite; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 845616-12-8
2-bromo-5-cyanobenzoic acid

: 1456892-09-3
3-((1R,3S,6S)-3-(((5-chloropyridin-2-yl)oxy)methyl)-2-azabicyclo[4.1.0]heptane-2-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 1 h / 25 °C

1.2: 1.5 h / 80 °C

2.1: cesium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; cesium fluoride; In 1,4-dioxane; N,N-dimethyl-formamide;