(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

Base Information

Chemical Name:(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one
CAS No.:165672-68-4
Molecular Formula:C₁₃H₁₇NO₃
Molecular Weight:235.283
Hs Code.:

Synonyms:(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

There total 7 articles about (5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92912-21-5
ethyl 1-benzyl-3,6-dioxo-2-piperidinecarboxylate

: 165672-68-4
(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / baker's yeast / H₂O

2: 98 percent / Huenig base / CHCl₃ / Heating

3: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C

4: 96 percent / NaH / dimethylformamide; benzene

5: conc. HCl / methanol / Heating

6: PCC, AcONa / CH₂Cl₂

7: 1.) H₂, 2.) NaB(OAc)3H / 1.) Pd(OH)2 / 1.) MeOH, 2.) AcOH

With hydrogenchloride; baker's yeast; hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; sodium hydride; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo990397t

Reference yield:

: 165672-46-8
(2R,3S)-1-Benzyl-3-hydroxy-6-oxo-piperidine-2-carboxylic acid ethyl ester

: 165672-68-4
(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / Huenig base / CHCl₃ / Heating

2: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C

3: 96 percent / NaH / dimethylformamide; benzene

4: conc. HCl / methanol / Heating

5: PCC, AcONa / CH₂Cl₂

6: 1.) H₂, 2.) NaB(OAc)3H / 1.) Pd(OH)2 / 1.) MeOH, 2.) AcOH

With hydrogenchloride; hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; sodium hydride; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo990397t

Reference yield:

: 165672-49-1
(5S,6S)-1-Benzyl-6-hydroxymethyl-5-methoxymethoxy-piperidin-2-one

: 165672-68-4
(5R,6S)-1-Benzyl-5-hydroxy-6-hydroxymethyl-piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaH / dimethylformamide; benzene

2: conc. HCl / methanol / Heating

3: PCC, AcONa / CH₂Cl₂

4: 1.) H₂, 2.) NaB(OAc)3H / 1.) Pd(OH)2 / 1.) MeOH, 2.) AcOH

With hydrogenchloride; hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; sodium hydride; pyridinium chlorochromate; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo990397t