<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

Base Information

Chemical Name:<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester
CAS No.:156824-43-0
Molecular Formula:C₁₁H₈F₃N₃O₅
Molecular Weight:319.197
Hs Code.:

Synonyms:<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

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Chemical Property of <2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

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Technology Process of <2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

There total 13 articles about <2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 152565-40-7
<3-<3-(Trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

: 156824-43-0
<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

Guidance literature:: With nitric acid; acetic anhydride; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.42.826

Reference yield:

: 113787-85-2
3-(3-hydroxyhenyl)-3-(trifluoromethyl)-3H-diazirine

: 156824-43-0
<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃, 18-crown-6 / tetrahydrofuran / 18 h / Ambient temperature

2: 75 percent / nitric acid, acetic anhydride / 0.5 h / Ambient temperature

With 18-crown-6 ether; nitric acid; acetic anhydride; potassium carbonate; In tetrahydrofuran;
DOI:10.1248/cpb.42.826

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 156824-43-0
<2-Nitro-5-<3-(trifluoromethyl)-3H-diazirin-3-yl>phenoxy>acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Mg / 1.) THF, 2.) THF, r.t., 2 h

2: 96 percent / hydroxylamine hydrochloride, pyridine / ethanol / 12 h / 60 °C

3: Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 0.75 h / Ambient temperature

4: liq. NH₃ / CH₂Cl₂ / 18 h / Ambient temperature

5: 77 percent / tert-butyl hypochlorite, Et₃N / ethanol; 2-methyl-propan-2-ol / 2 h / Ambient temperature

6: 92 percent / BBr₃ / CH₂Cl₂ / 7 h / 0 °C

7: K₂CO₃, 18-crown-6 / tetrahydrofuran / 18 h / Ambient temperature

8: 1.) thallium(III) trifluoroacetate, 2.) NaNO₂ / 1.) TFA, r.t., 2.) r.t., 30 min

With pyridine; dmap; 18-crown-6 ether; tert-butylhypochlorite; hydroxylamine hydrochloride; ammonia; boron tribromide; potassium carbonate; magnesium; triethylamine; sodium nitrite; thallium(III) trifluoroacetate; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00081a017