3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

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Chemical Name:3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt
CAS No.:1446176-65-3
Molecular Formula:C₆H₁₅N*C₃₄H₂₈FN₃O₇
Molecular Weight:710.802
Hs Code.:

3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

Synonyms:3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

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Chemical Property of 3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

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Technology Process of 3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

There total 8 articles about 3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 880157-10-8
benzyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1446176-58-4
6-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: 1446176-65-3
3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

Guidance literature:: benzyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 6-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; potassium carbonate; In N,N-dimethyl-formamide; at 95 ℃; for 1h; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 74439-45-5
ethyl 1-benzyl-6-hydroxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 1446176-65-3
3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

Guidance literature:: Multi-step reaction with 8 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

5: sulfuric acid / 1 h / 50 °C

6: sodium hydrogencarbonate; N-iodo-succinimide / 1,4-dioxane / 24 h / 20 °C

7: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

8: potassium carbonate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sulfuric acid; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1446176-52-8
ethyl 1-benzyl-6-chloro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 1446176-65-3
3-{3-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid triethylamine salt

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

4: sulfuric acid / 1 h / 50 °C

5: sodium hydrogencarbonate; N-iodo-succinimide / 1,4-dioxane / 24 h / 20 °C

6: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C

7: potassium carbonate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sulfuric acid; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;