1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

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Chemical Name:1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS No.:186386-09-4
Molecular Formula:C₂₉H₃₅F₃N₄O₃
Molecular Weight:544.617
Hs Code.:

Synonyms:1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

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Technology Process of 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

There total 7 articles about 1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 592527-80-5
toluene-4-sulfonic acid 2,2-dimethyl-3-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl ester

: 1-benzylthymine sodium salt

: 186386-09-4
1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With sodium hydride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 85 ℃;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 36881-15-9
3-(benzyloxy)-2,2-dimethylpropanoyl chloride

: 186386-09-4
1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / benzene / 0 °C

2: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

3: HCO₂NH₄ / Pd/C / methanol

4: 95 percent / Et₃N; DMAP / CH₂Cl₂

5: 73 percent / NaH / hexamethylphosphoric acid triamide / 85 °C

With dmap; lithium aluminium tetrahydride; ammonium formate; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; benzene;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 178671-99-3
1-[2-(2,2,2-trifluoroethoxy)-phenyl]-piperazine

: 186386-09-4
1-benzyl-3-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}-2,2-dimethylpropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / benzene / 0 °C

2: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

3: HCO₂NH₄ / Pd/C / methanol

4: 95 percent / Et₃N; DMAP / CH₂Cl₂

5: 73 percent / NaH / hexamethylphosphoric acid triamide / 85 °C

With dmap; lithium aluminium tetrahydride; ammonium formate; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; benzene;
DOI:10.1016/S0960-894X(03)00305-6