8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

Base Information

Chemical Name:8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane
CAS No.:164987-80-8
Molecular Formula:C₃₂H₄₁N₃O₈S₃
Molecular Weight:691.891
Hs Code.:

Synonyms:8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

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Chemical Property of 8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

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Technology Process of 8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

There total 1 articles about 8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56187-04-3
1,4,7-tritosyl-1,4,7-triazaheptane

: 164987-79-5
1,5-Dibromopentan-3-one ethylene ketal

: 164987-80-8
8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

Guidance literature:: With caesium carbonate; Yield given. Multistep reaction; 1.) DMF, 100 deg C, 3 h, 2.) DMF;
DOI:10.1021/ja00125a005

Reference yield: 92.0%

: 164987-80-8
8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

: 164987-86-4
1,4,7-tris(p-tolylsulfonyl)-1,4,7-triazacyclododec-10-one

Guidance literature:: With perchloric acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/ja00125a005

Reference yield:

: 164987-80-8
8,11,14-Tris-(toluene-4-sulfonyl)-1,4-dioxa-8,11,14-triaza-spiro[4.11]hexadecane

: 10-(phenylthio)-1,4,7-triazacyclododecane

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / 69percent aq. HClO₄ / CH₂Cl₂ / 2 h / Ambient temperature

2: 88 percent / NaBH₄ / methanol / 15 h / Ambient temperature

3: 1.) NaH, imidazole / 1.) THF, reflux, 2 h, 2.) THF, reflux, 3 h

4: 45 percent / Li/NH₃ (liquid) / tetrahydrofuran / from -78 deg C to reflux

5: 73 percent / diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 - 20 °C

6: BBr₃ / CH₂Cl₂ / 0.25 h / 0 - 20 °C

7: 82 percent / diisopropylethylamine / CH₂Cl₂ / 0.25 h / 0 °C

8: 1.) NaH / 1.) dimethylimidazolone, 2.) dimethylimidazolone, 45 deg C, overnight

9: NH₃, CH₃OH

With 1H-imidazole; methanol; sodium tetrahydroborate; perchloric acid; ammonia; boron tribromide; lithium; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00125a005