Technology Process of ethyl 2-cinnamyl-2-hydroxy-3-oxo-7-(tosyloxy)heptanoate
There total 5 articles about ethyl 2-cinnamyl-2-hydroxy-3-oxo-7-(tosyloxy)heptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
benzene;
at 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/ol3020072
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 °C / Inert atmosphere
2.1: 4-acetamidobenzenesulfonyl azide / acetonitrile / 0.08 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Ionic liquid
3.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
4.1: rhodium (II) octanoate dimer / benzene / 0.5 h / 80 °C / Inert atmosphere
5.1: boron trifluoride diethyl etherate / benzene / 2 h / 20 °C / Inert atmosphere
With
rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; boron trifluoride diethyl etherate; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol3020072
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-acetamidobenzenesulfonyl azide / acetonitrile / 0.08 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Ionic liquid
2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
3.1: rhodium (II) octanoate dimer / benzene / 0.5 h / 80 °C / Inert atmosphere
4.1: boron trifluoride diethyl etherate / benzene / 2 h / 20 °C / Inert atmosphere
With
rhodium (II) octanoate dimer; 4-acetamidobenzenesulfonyl azide; boron trifluoride diethyl etherate; triethylamine;
In
dichloromethane; acetonitrile; benzene;
DOI:10.1021/ol3020072
