N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide
• CAS No.: 1449327-79-0
• Molecular Formula: C₂₈H₂₇NO₄S
• Molecular Weight: 473.593

Synonyms:N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Chemical Property of N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

There total 3 articles about N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H43NO4SSi → N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide (1449327-79-0)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; ethyl acetate; at 20 ℃; for 1.5h;

DOI:10.1016/j.tet.2013.05.056

Reference yield:

2,2-diphenylcyclopropanecarbaldehyde (59591-01-4) → N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide (1449327-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

1.2: 0.5 h / -78 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; ethyl acetate / 1.5 h / 20 °C

With n-butyllithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.tet.2013.05.056

Reference yield:

2,2-diphenylcyclopropylmethanol (37555-48-9) → N-[4-(2,2-diphenylcyclopropyl)-4-oxobut-2-ynyl]-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide (1449327-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

2.2: 0.5 h / -78 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; ethyl acetate / 1.5 h / 20 °C

With n-butyllithium; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.tet.2013.05.056

upstream raw materials:

2,2-diphenylcyclopropanecarbaldehyde

2,2-diphenylcyclopropylmethanol

Downstream raw materials:

hexacarbonyl-μ-{η⁴-2,2-diphenyl-9-tosyl-9-aza-1,6-dioxaspiro[4,7]dodec-11-yne}dicobalt

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