(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Base Information

Chemical Name:(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester
CAS No.:129122-74-3
Molecular Formula:C₂₈H₃₁FNO₅P
Molecular Weight:511.53
Hs Code.:

Synonyms:(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

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Chemical Property of (S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

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Technology Process of (S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

There total 18 articles about (S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129122-73-2
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[2-(4-fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester

: 129122-74-3
(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 19h; Ambient temperature;
DOI:10.1021/jm00113a019

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 129122-74-3
(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran / 1 h / -78 °C

7: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

8: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

9: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium ethanolate; Dess-Martin periodane; acetic acid; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 36597-08-7
(E)-4-methyl-1-phenyl-2-penten-1-one

: 129122-74-3
(S)-4-({(E)-2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran / 1 h / -78 °C

7: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

8: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

9: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium ethanolate; Dess-Martin periodane; acetic acid; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019