7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

Base Information

Chemical Name:7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin
CAS No.:346694-44-8
Molecular Formula:C₄₆H₇₂O₁₂
Molecular Weight:817.07
Hs Code.:

Synonyms:7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

Chemical Property:

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Technology Process of 7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

There total 6 articles about 7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 346694-25-5
6-{2'-ethyl-5'-[9-(4-ethyl-benzyloxy)-7-(2-methoxy-3-methoxycarbonyl-1-methyl-butyl)-2,8-dimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3-methyl-octahydro-[2,2']bifuranyl-5-yl}-2-methoxy-3,5-dimethyl-tetrahydro-pyran-2-carboxylic acid

: 346694-44-8
7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/S0040-4020(01)00154-5

Reference yield:

: 116278-62-7
25-O-methylmonensin methyl ester

: 346694-44-8
7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / imidazole / tetrahydrofuran / 22 h / 20 °C

2: 62 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C

3: 95 percent / TBAF*3H₂O / tetrahydrofuran / 20 °C

4: 85 percent / pyridinium dichromate; molecular sieves 4A; Celite / CH₂Cl₂ / 20 °C

5: 84 percent / NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

6: 58 percent / sodium hydroxide / methanol; tetrahydrofuran / 20 °C

With 1H-imidazole; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 4 A molecular sieve; Celite; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)00154-5

Reference yield:

: 244088-32-2
25-O-methyl-26-O-t-butyldimethylsilylmonensin methyl ester

: 346694-44-8
7-O-p-ethylbenzyl-25-O-methyl-25-carboxymonensin

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 20 °C

2: 95 percent / TBAF*3H₂O / tetrahydrofuran / 20 °C

3: 85 percent / pyridinium dichromate; molecular sieves 4A; Celite / CH₂Cl₂ / 20 °C

4: 84 percent / NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

5: 58 percent / sodium hydroxide / methanol; tetrahydrofuran / 20 °C

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 4 A molecular sieve; Celite; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(01)00154-5