5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

Base Information

Chemical Name:5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine
CAS No.:213206-79-2
Molecular Formula:C₂₃H₂₄FNO₃S
Molecular Weight:413.513
Hs Code.:

Synonyms:5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

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Chemical Property of 5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

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Technology Process of 5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

There total 5 articles about 5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 213206-76-9
5-isopropoxy-2-[(4-methoxybenzyl)thio]phenyl 4-fluoro-2-nitrophenyl ether

: 213206-79-2
5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

Guidance literature:: With acetic acid; zinc; In tetrahydrofuran; methanol; for 0.5h; Ambient temperature;
DOI:10.1002/jhet.5570350332

Reference yield:

: 4991-65-5
tioxolone

: 213206-79-2
5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 3.5 h / Ambient temperature

2: aq. KOH / methanol / 0.17 h / Ambient temperature

3: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT

4: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h

5: 100 percent / Zn, aq. AcOH / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

With potassium hydroxide; 18-crown-6 ether; potassium tert-butylate; sodium hydride; potassium carbonate; acetic acid; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350332

Reference yield:

: 205187-15-1
5-isopropoxy-2-mercaptophenol

: 213206-79-2
5-Fluoro-2-[5-isopropoxy-2-(4-methoxy-benzylsulfanyl)-phenoxy]-phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, from 0 deg C to RT

2: 1.) NaH, 2.) 18-crown-6 / 1.) diglyme, RT, 15 min, 2.) diglyme, reflux, 2 h

3: 100 percent / Zn, aq. AcOH / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

With 18-crown-6 ether; potassium tert-butylate; sodium hydride; acetic acid; zinc; In tetrahydrofuran; methanol;
DOI:10.1002/jhet.5570350332