Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

Base Information

Chemical Name:Fmoc-β3hPhe(3-Boc-HN-CH2)-OH
CAS No.:1348993-89-4
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

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Chemical Property of Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

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Technology Process of Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

There total 11 articles about Fmoc-β3hPhe(3-Boc-HN-CH2)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1348994-02-4
Fmoc-Phe(3-Boc-HN-CH₂)-CHN₂

: 1348993-89-4
Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

Guidance literature:: With water; silver benzoate; In 1,4-dioxane; at 90 ℃; for 5h;
DOI:10.1016/j.bmc.2011.09.050

Reference yield:

: 1348993-96-3
Pht-Phe(3-Boc-HN-CH₂)-OMe

: 1348993-89-4
Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate; acetic acid / methanol / 20 °C

1.2: pH 8 - 9

1.3: pH Ca_. 4

2.1: water; sodium hydroxide / 1,4-dioxane / 3 h / 20 °C

3.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / pH 8 - 9

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

4.2: -5 - 20 °C / Inert atmosphere

5.1: water; silver benzoate / 1,4-dioxane / 5 h / 90 °C

With water; silver benzoate; chloroformic acid ethyl ester; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 5.1: Arndt-Eistert homologation;
DOI:10.1016/j.bmc.2011.09.050

Reference yield:

: 1348993-91-8
Pht-Phe(3-CN)-OMe

: 1348993-89-4
Fmoc-β3hPhe(3-Boc-HN-CH2)-OH

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid / water / 120 h / 20 °C / 3600.36 Torr

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 4.5 h / 20 °C

3.1: hydrazine hydrate; acetic acid / methanol / 20 °C

3.2: pH 8 - 9

3.3: pH Ca_. 4

4.1: water; sodium hydroxide / 1,4-dioxane / 3 h / 20 °C

5.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / pH 8 - 9

6.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.25 h / -15 °C / Inert atmosphere

6.2: -5 - 20 °C / Inert atmosphere

7.1: water; silver benzoate / 1,4-dioxane / 5 h / 90 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; silver benzoate; chloroformic acid ethyl ester; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 7.1: Arndt-Eistert homologation;
DOI:10.1016/j.bmc.2011.09.050