(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

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Chemical Name:(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid
CAS No.:1307802-01-2
Molecular Formula:C₂₃H₂₇N₅O₂
Molecular Weight:405.5
Hs Code.:

Synonyms:(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

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Chemical Property of (S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

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Technology Process of (S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

There total 7 articles about (S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₈N₄O

: 72580-53-1
(S)-(+)-3-pyrrolidinecarboxylic acid

: 1307802-01-2
(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2015.09.011

Reference yield:

: C₁₃H₁₅N₃O₄S

: 1307802-01-2
(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: dipyridinium dichromate / dichloromethane / 20 °C

4: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2015.09.011

Reference yield:

: C₁₃H₁₅N₃O₂S

: 1307802-01-2
(S)-1-((1-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl)methyl)pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: hydrogenchloride / ethanol; water / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: dipyridinium dichromate / dichloromethane / 20 °C

5: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; sodium tris(acetoxy)borohydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2015.09.011