(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

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Chemical Name:(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one
CAS No.:180153-04-2
Molecular Formula:C₂₈H₄₁NO₅Si
Molecular Weight:499.723
Hs Code.:

Synonyms:(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

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Chemical Property of (S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

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Technology Process of (S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

There total 4 articles about (S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 180153-03-1
(S)-3-[(1S,2R)-2-Ethoxy-3-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-cyclobutyl]-4-phenyl-oxazolidin-2-one

: 180153-04-2
(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

Guidance literature:: With disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 8h;
DOI:10.1021/jo960664k

Reference yield:

: 180153-12-2
1-iodo-4-(tri-iso-propyl)silyl-3-butyne

: 180153-04-2
(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuLi, 4.) irradiation

2: 99 percent / m-chloroperbenzoic acid, Na₂HPO₄ / CH₂Cl₂ / 8 h / 25 °C

With disodium hydrogenphosphate; tert.-butyl lithium; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo960664k

Reference yield:

: 180153-11-1
4-(triisopropylsilyl)but-3-yn-1-ol

: 180153-04-2
(S)-3-[(2S,3S)-2-Ethoxy-5-oxo-2-(4-triisopropylsilanyl-but-3-ynyl)-tetrahydro-furan-3-yl]-4-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 17 h / 25 °C

2: 3.6 g / NaI / acetone / 24 h / Heating

3: 1.) t-BuLi, 4.) irradiation

4: 99 percent / m-chloroperbenzoic acid, Na₂HPO₄ / CH₂Cl₂ / 8 h / 25 °C

With disodium hydrogenphosphate; tert.-butyl lithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jo960664k