N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

Base Information

Chemical Name:N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide
CAS No.:131066-46-1
Molecular Formula:C₁₇H₂₇N₂O₅P
Molecular Weight:370.386
Hs Code.:

Synonyms:N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

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Chemical Property of N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

Chemical Property:

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Technology Process of N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

There total 5 articles about N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3070-69-7
methyl 2-(2-methylpropyl)acrylate

: 131066-46-1
N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine, 2.) ammonia / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; ammonia; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 131066-43-8
N-benzyloxycarbonylaminomethyl-H-phosphinic acid

: 131066-46-1
N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: bis(trimethylsilyl)acetamide (BSA) / acetonitrile / Ambient temperature

2: acetonitrile; methanol; diethyl ether / 0 °C

3: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

4: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine, 2.) ammonia / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; ammonia; bis-(trimethylsilyl)acetamide; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043

Reference yield:

: 2-[(Benzyloxycarbonylamino-methyl)-hydroxy-phosphinoylmethyl]-4-methyl-pentanoic acid methyl ester

: 131066-46-1
N-2(S)-<<<(N-carbobenzoxyamino)methyl>methoxyphosphinyl>methyl>-4-methylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile; methanol; diethyl ether / 0 °C

2: 27 percent / 0.055 M borate buffer (pH 8.1) / 24 h / subtilisin Carlsberg (protease IV)

3: 1.) isobutyl chloroformate (IBCF), N-methylmorpholine, 2.) ammonia / 1.) CH₃CN, -5 deg C, 3 min, 2.) a) -5 deg C, 2 h, b) RT, 2 h

With 4-methyl-morpholine; borate buffer; ammonia; isobutyl chloroformate; In methanol; diethyl ether; acetonitrile;
DOI:10.1021/ja00001a043