tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate
CAS No.:1437800-75-3
Molecular Formula:C₂₁H₂₉F₂N₃O₅S
Molecular Weight:473.541
Hs Code.:

Synonyms:tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

: 1437800-81-1
tert-butyl 4-(2-(2,5-difluoro-4-(methylsulfonyl)benzylamino)ethylamino)piperidine-1-carboxylate

: 530-62-1
1,1'-carbonyldiimidazole

: 1437800-75-3
tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃; for 4h;

Reference yield:

: 1437800-76-4
benzyl 4-bromo-2,5-difluorobenzyl(2-((tert-butoxycarbonyl)amino)ethyl)carbamate

: 1437800-75-3
tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 1 h / 20 °C

2.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: rac-diaminocyclohexane; copper (I) trifluoromethane sulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 60 °C

With copper (I) trifluoromethane sulfonate benzene; palladium 10% on activated carbon; hydrogen; acetic acid; rac-diaminocyclohexane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1437800-78-6
benzyl 2-aminoethyl(4-bromo-2,5-difluorobenzyl)carbamate trifluoroacetic acid

: 1437800-75-3
tert-butyl 4-(3-(2,5-difluoro-4-(methylsulfonyl)benzyl)-2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / tetrahydrofuran / 0.5 h / 20 °C

1.2: 20 °C

2.1: rac-diaminocyclohexane; copper (I) trifluoromethane sulfonate benzene / dimethyl sulfoxide / 110 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 60 °C

With copper (I) trifluoromethane sulfonate benzene; palladium 10% on activated carbon; hydrogen; acetic acid; rac-diaminocyclohexane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;